Document Type : Research Article
Authors
1 university of Baghdad
2 Biochemistry Department / College of Medicine/ University of Baghdad- Baghdad- Iraq
Abstract
Background: Breast carcinoma, a malignant neoplasm originating from breast tissue, exhibits a remarkable pathological diversity that underscores its complexity. However, the pathological manifestations of this disease are multifaceted, encompassing various histological subtypes and molecular classifications. In 2018, over 2 million new cases of breast cancer were estimated to occur globally, accounting for nearly 12% of all new cancer cases. Circular RNAs (microRNAs) have recently gained attention as a novel class of non-coding RNAs with diverse gene regulatory functions among the various epigenetic regulators.
Subjects and methods: The study includes 100 women with age range 23 to 80 years old. They were divided into two groups: Group A include 48 women with newly diagnosis breast cancer. And group B include 52 women without breast cancer or any others cancers. Laboratory investigation included measurement of miR-21, CA 15-3, HbA1c, Lipid profile, liver function, renal function.
Results: The mean ± SD for women without breast cancer was 8.64 ± 2.17, while for women with breast cancer patients, it was 46.32 ± 11.28. The p-value was 0.000, indicating statistical significance. In conclusion, our study proven an increase in micro RNA-21 with breast cancer compared to individuals without cancer. Micro RNA-21 used as biochemical marker for breast cancer. CA 15-3, also increased with the presence of breast cancer.
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