Document Type : Research Article

Authors

• Nawar S Taher ¹
• Suhad H Mohammed ²

¹ College of Applied Medical Sciences /The Department of Pathological analyzes/ University of Karbala/Iraq

² University of Kerbala College of Applied Medical Sciences The Department of Clinical laboratories

Abstract

Bacterial translocation (BT) has not completely defined in patients with Hepatitis B, C viruses, and Liver cirrho-sis. This study aims to study the differences in the LPS level as a marker for BT among patients with HBV, HCV, and liver cirrhosis and their effect on disease severity. Across-sectional study was conducted. Out of 89 blood samples was collected from patients with HBV, HCV, liver cirrhosis. Serum samples was used to measure the lev-el of LPS automatically by ELISA Techniques. SPSS, version 22 software, was used to analyze data. Out of 50.56% of patients were infected with HBV, 23.59% were infected with HCV and 25.84% with liver cirrhosis. There were significant lower mean of LPS in patients with HBV in comparison to HCV and liver cirrhotic pa-tients. Significant positive correlation of LPS with ALP was found. The highest mean in LPS level that found in liver cirrhotic patients may reflect the impact of LPS in pathogenesis. Significant positive correlation of LPS with ALP may support the role of these parameter in disease pathogenesis.

Keywords

• Viral hepatitis,,
• ,،HBV,,
• ,،HC,,
• ,،liver cirrhosis,,
• ,،Bacterial translocation,,
• ,،Lipopolysaccharide (LPS)