Document Type : Review Article


Janan Nima Hadi



This study highlights the use of plant-derived natural surfactants in formulating pharmaceutical emulsions, addressing concerns with traditional synthetic surfactants. Emulsions are vital for enhancing drug bioavailability, but their formulation often involves environmentally concerning agents. Natural surfactants from plant extracts emerge as eco-friendly alternatives. The review explores diverse plant-derived surfactants, emphasizing their unique structures and surface-active properties. Extraction methods, purification techniques, and their compatibility with pharmaceutical ingredients are evaluated, showcasing their efficacy in stabilizing emulsions. Physicochemical aspects of emulsion stability, including interactions between natural surfactants, co-surfactants, and hydrophobic drugs, are discussed. Case studies demonstrate successful formulations across various pharmaceutical emulsion systems, highlighting their potential in controlled drug delivery. Safety is crucial, especially in pharmaceuticals. The abstract reviews toxicity, irritation, and allergies tied to plant-derived surfactants, confirming their suitability. In conclusion, integrating natural surfactants from plant extracts in pharmaceutical emulsions offers a biocompatible and sustainable approach to enhancing drug delivery. This research emphasizes the need for further studies to optimize formulations, assess long-term stability, and validate their clinical potential.